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Getting Started

Welcome to SciveraLENS Rapid Screen! This article is a quick overview of the application and some quick tips for getting up and running on the system. This short article will get you entering chemicals and generating results right away. There is more detail on each of these steps in other areas of this User Guide.

The three things to learn for quick use of SciveraLENS Rapid Screen are:

(1) Create a Collection

(2) Review screening results for each Collection

(3) Understand Alerts to stay up to date on changes to screening results over time.

Create a “Collection”, or How to get data into your Rapid Screen account :: Rapid Screen organizes your chemicals of interest into Collections. A Collection of chemicals can be a single chemical, or a list of chemicals. Your list of chemicals can be a formulation for an adhesive product, or it could be a list of solvents that you would like to compare for use in a specific application. Collections can be chemicals organized for any purpose. The way you organize your Collections is only limited by your imagination or chemicals management needs.

Create Collections in Rapid Screen using one of three different methods:

(1) Import a Safety Data Sheet (SDS) :: i.e., Get a PDF from your supplier, upload it, and you are all set

[Here is a Sample SDS to try out this form of Collection creation](2) Use the super easy 3-step “BOS Builder” web form tool :: Name your Collection, add chemicals of interest by name or CASRN (Chemical Abstract Service Registry Number), and attach the Regulated, Screening, or Preferred Chemical Lists against which you’d like to review/track your Collection. By the way, BOS is an acronym for “bill of substances.” A BOS is a data document, similar to the long used term, BOM, (bill of materials) but with the additional information of specific chemicals that make up each material.

Here is a list of 3 chemicals to use in the BOS Builder web wizard to create a Collection using this method:

  1. Water [CASRN: 7732-18-5] 75% (use decimal value of 0.75 for concentration)
  2. 1-butoxypropan-2-ol [CASRN: 5131-66-8] 20% (aka 0.2)
  3. 2-(2-methoxyethoxy)ethanol [CASRN: 111-77-3] 5% (aka 0.05)

(3) Upload a formatted data file from a spreadsheet :: In addition to using the above SDS import or BOS Builder, you can create a Collection in a spreadsheet and upload it to your Rapid Screen account for screening a tracking. There is a specific format for the data (i.e., basic fields, etc) needed for a successful upload. This approach can be very useful for large Collections or for pulling data from an existing data resource. Feel free to check with our Support Team if you’d like to discuss bulk data import from an existing system to your Rapid Screen account.

[Here is a Sample CSV File to try out the spreadsheet data file upload method to create a Collection]To create Collection using one of the above methods, click on “Collections” in the navigation menu on the left side of your Rapid Screen app window (see red box in image below).

Then click on the green circle with a “+” symbol in the upper right of the window.

You will then see a pull down menu of the three options for creating a Collection. Give it a try. Send us a note if you have any trouble creating a Collection, or check out the specific User Guide articles for each of the three Collection creation options.

Once you have created your first Collection, you can then have a look at the screening results. Your new collection will be listed in the main area of the Collections window.

Review screening results for each Collection :: Or how to get answers to your chemicals management questions, instantly.

When in the Collections page, you will see your current list of Collections. Each Collection will include two symbols to the left of the Collection name. The triangle symbol shows the result of the List Screen completed for the chemicals in each Collection.

Red Triangle = One or more List “Hits” for one or more chemicals in the Collection.

Yellow Triangle = One or more List “Hits” for chemical(s) but the concentration used in the Collection does not exceed the threshold for that chemical in the list.

Blue Triangle = No list hits for selected Lists for that Collection.

The circular symbol (aka “traffic light”) is the instant result of the Human and Environmental Health Screen for the chemicals in the Collection. This “MaxHaz” result is based on the highest hazard assessment across all chemicals in the Collection and across all 22 Human and Environmental Health Endpoints for each chemical.

Green = Low Hazard

Gray/Green = Low Hazard based on limited evidence only (e.g., modeling, QSAR, etc.)

Yellow = Moderate Hazard

Gray/Yellow = Moderate Hazard based on limited evidence only (e.g., modeling, QSAR, etc.)

Red = High Hazard

Gray/Red = High Hazard based on limited evidence only (e.g., modeling, QSAR, etc.)

Black = Very High Hazard

Gray/Black = Very High Hazard based on limited evidence only (e.g., modeling, QSAR, etc.)

Gray = No List Evidence, but insufficient authoritative, experimental, or modeling/QSAR data to make an assessment

Blue = No list evidence – In queue for complete assessment by Scivera Toxicology Team

SciveraLENS Symbols Explained

Here is a quick glossary of the symbols you will see throughout SciveraLENS Rapid Screen

List Screening Results

SciveraLENS Rapid Screen enables you to easily assign one, several, or all of the dozens of lists we track on a daily basis to help to stay current on regulatory, industry, authoritative, and corporate governance trends. The most common “List” of chemicals we track is what’s called a Restricted Substance List (aka “RSL”). These are lists published and updated by various authorities and organizations. A well-known RSL is “The Proposition 65 List”, more formally known as “Chemicals Known to the State of California to Cause Cancer or Reproductive Toxicity.”

Other lists of interest include authoritative lists published by academic or scientific organizations such as the United Nations International Agency for Research on Carcinogens (“IARC”). Non-governmental organizations (“NGO”) publish what are commonly called “screening lists” of chemicals with specific characteristics of concern. Many industry groups and companies refer to these screening lists in setting governance policies on chemicals on products or processes.

Lastly, organizations are increasingly developing “preferred lists” or “positive lists” of chemicals that have been screened for specific uses and show comparatively preferred human and/or environmental health attributes. The US Environmental Protection Agency (EPA) maintains a Safer Chemical Ingredients List (“SCIL”) that can be a useful reference when seeking preferred alternatives for specific applications.

Keeping up with all of these lists and their nuances and changes is a time consuming and challenging task. SciveraLENS Rapid Screen begins its chemicals management process doing these basic list checking steps for you and keeping you up to date on any changes to your chemicals of interest using alerts.

 The blue triangle indicates your list(s) of interest were checked, and no hits

The yellow triangle indicates your lists of interest were checked, and there are one or more list(s) hit but chemical concentration is below a set threshold for the list(s).

The red triangle indicates that your lists of interest were checked, and there are one or more hits above a set concentration threshold

Human and Environmental Health Screen Results

SciveraLENS makes use of an easy to understand “traffic light” system for communicating assessment results for human and environmental health attributes of specific endpoints and for a chemical overall.

A solid green, yellow, red, or black light indicates sufficient authoritative or experimental evidence for an unequivocal hazard assessment.

When half of the light is gray, this indicates limited evidence is currently available for the endpoint and Scivera’s Toxicology Team has made use of systems such as modeling software, quantitative structural activity relationship (“QSAR”) methods, or expert judgment to complete the assessment.

Clicking on the light for a specific endpoint assessment will present the underlying references and explanation for why Scivera reached the specific conclusion indicated by the light.

 
Green is good. Green lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of low hazard.

 
Yellow is acceptable. Yellow lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of moderate hazard.

 
Red indicates concern. Red lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of high hazard.

 
Black indicates high concern. Black lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of high hazard.


Light blue indicates potential, but with caution. Many chemicals have not been tested for a many different hazards. Light blue signals the endpoint does not show concern for the designated endpoint based on list evidence only.


The light blue and gray light indicates an endpoint or chemical overall that does not show list evidence of concern, but after additional work by our toxicology team, we are not currently able to conclude an assessment. Data are currently not sufficient for an assessment.

Scivera’s Toxicology Team has this chemical and endpoint in its assessment queue for deeper review via the expert methods mentioned above (e.g., computer modeling, QSAR, expert judgment, etc.). Scivera prioritizes this additional review based on subscriber interest in chemicals across the SciveraLENS system. If you would like Scivera to expedite an assessment for your work and provide a firm date for completion, contact our Customer Success Team at support@scivera.com to receive and quote and a completion date for that task.

SciveraLENS Human and Environmental Health Endpoints Explained

SciveraLENS Rapid Screen generates an overall hazard assessment for each chemical present in a collection. SciveraLENS processes chemical hazard assessments using authoritative lists, regulatory lists, experimental data, modeled data, analogous data, and expert judgment.

See User Guide article SciveraLENS GHSplus Hazard Assessment Framework and related Restricted Substance Lists and Screening Lists for specifics on Hazard and Dose-Response Assessment criteria by endpoint. SciveraLENS generates a hazard assessment at two levels for a chemical:

Endpoint Level Hazard Assessment – Where data and/or expert judgment enable an assessment, Scivera’s board-certified toxicology team generate a hazard assessment for up to 17 Human Health and 5 Ecotox and Environmental Fate endpoints.

Human Health Endpoints include:

  • Carcinogenicity [C]
  • Mutagenicity-Genotoxicity
[M]
  • Reproductive Toxicity [R]
  • Developmental Toxicity [D]
  • Endocrine Disruption
[ed]
  • Acute Oral Toxicity [ato]
  • Acute Dermal Toxicity
[atd]
  • Acute Inhalation Toxicity [ati]
  • Eye Irritation
[ei]
  • Dermal Sensitization [ds]
  • Respiratory Sensitization [rs]
  • Dermal Irritation
[di]
  • Systemic Toxicity (Single Dose) [st-s]
  • Systemic Toxicity (Repeat Dose) [st-r]
  • Neurotoxicity
[n]
  • Sensory Irritation
[si]
  • Aspiration Potential [ap]

Environmental Health (Ecotox and Environmental Fate) Endpoints include:

  • Persistence [P]
  • Bioaccumulation
[B]
  • Acute Aquatic Toxicity
[AAT]
  • Chronic Aquatic Toxicity [CAT]
  • Soil Toxicity
[st]
  • Degradation of Organic Chemicals [doc]
  • Ozone Depletion [od]

Note: Underlined endpoints are CORE endpoints. All Core Endpoints must have conclusive assessments for the chemical to have a conclusive assessment overall.

Core Endpoints require conclusive data to generate a conclusive hazard assessment for the chemical.

Conclusive data for Supplemental Endpoints are not required except in the case of a Preferred or Acceptable Chemical overall assessment, but support the overall hazard assessment for the chemical.

Each chemical’s hazard assessment is based on a set of conditions relative to each endpoint. SciVera Lens implements a matrix of criteria for each endpoint and data point type within each endpoint that results in an appropriate hazard condition.

SciveraLENS implements a rules algorithm to generate a provisional hazard assessment for each endpoint, category, and overall for each chemical across its Core and Supplemental Endpoints using a combination of data from authoritative lists, data from experimental studies, modeled data, analogous data, and expert judgment. Modeled and analogous data help to close data gaps for chemicals with endpoints where experimental or authoritative data are lacking. SciVera’s team of toxicologists and researchers then reviews these provisional results performs a quality assurance step and confirms the provisional hazard assessment for each chemical.

One example of a data point type in the Carcinogenicity endpoint is the International Agency for Research on Cancer (IARC) authoritative list. If the chemical is listed on the IARC list, that chemical will have an “IARC Group Classification” assigned to it. Each IARC Group Classification results in a corresponding hazard condition for the chemical with regard to carcinogenicity. The chemical formaldehyde has an IARC Group Classification of 1; “known to cause cancer in humans.” This IARC Group Classification corresponds to a Very High or Black color code hazard assessment in SciVera Lens.

Creating New Chemical Collections

Create a Collection of Chemicals in Rapid Screen

There are three ways to create a new Collection in your Rapid Screen account (Remember, a collection is just a group of chemicals that you’re interested in tracking). The method you choose can depend of the type of information you have available, your preferred way of working, and/or the number of chemicals you’d like to track in Rapid Screen.

BOS Builder is a step-by-step web form in your Rapid Screen account that many of our SciveraLENS Enterprise brands and suppliers already use for data import. BOS stands for “Bill of Substances,” an increasingly common data document used to communicate the chemicals, materials, and components in a product. You can use BOS Builder to create a new Collection in 3 easy steps. (1) Name your new Collection, (2) Add your chemicals of interest to the new Collection, and (3) assign the lists (if any) you’d like to track against this new collection. BOS Builder is ideal for quickly adding a new Collection of just a few chemicals. It’s handy for adding formulations, or for adding a group of chemicals with similar functions for a quick alternatives assessment.

The second method of adding a collection is our Upload BOS tool. This process allows you to upload a spreadsheet file of your chemical data right into Rapid Screen using a very basic format. We have created a template to make this process easy to use, especially if you have a large number of Collections you would like to add to Rapid Screen. One of the most effective uses of the BOS Upload method to create a Collection is for a Basic Substance List (“BSL”). Many companies manage a BSL for all of the unique chemicals used in a process, a facility, or across their entire enterprise. Uploading a spreadsheet with your company’s BSL into Rapid Screen can be a very useful way to track those chemicals against your lists of interest, and follow those chemicals for their underlying Human and Environmental Health attributes.

The Upload SDS method allows you to import a PDF file of a Safety Data Sheet (SDS) right into your Rapid Screen account. Rapid Screen will take the product name and chemical ingredient  data from your SDS and create a new Collection using that information. You will then be asked to  review this data for accuracy and completeness before moving on to assigning  lists for screening. Many suppliers will initially only be able (or willing) to communicate their product chemicals via the Safety Data Sheet. This can be a very effective first step in gathering and tracking better chemicals information from suppliers. The SDS Upload tool in Rapid Screen can make the data entry process very fast, accurate, and efficient.

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