User Guide / Getting Started with SciveraLENS

Getting Started with SciveraLENS

Welcome!

Welcome to the Scivera community and to your SciveraLENS account! SciveraLENS helps you manage your data gathering, list screening, and chemical hazard assessments for product and process chemistries in a simple, fast, and accessible way. This information allows you to make safer chemicals decisions to protect your workers, your brand, and your customers.

This getting started guide will walk you through your SciveraLENS account and get you familiar with the different sections of the software. We have other articles in this User Guide that can provide you with additional information about each section as well as an FAQ guide. Don’t forget, you can always reach out to us at support@scivera.com should you have any questions.

Let’s get started!

Overview:

Once you’ve set up your account and entered the SciveraLENS system, you’ll see an Overview page. This page is your own personal SciveraLENS dashboard that will change and update as you use the system.

Your dashboard will look different depending on your level of subscription. Each tile on the Overview page tells you something about your subscription and subscription usage. For example, if you have one of our paid SciveraLENS subscriptions, the CAS RNs tile is a great place to keep an eye on the number of unique CAS RNs you have entered into your account and help you monitor how close you are to your CAS RN limit.

Collections:

SciveraLENS works by giving you the opportunity to enter chemicals of interest and view the assessment results available for each. Collections is where you start when using SciveraLENS and where you will be able to enter the chemicals or requests in order to generate the list screening and chemical hazard assessment results in SciveraLENS.

Collection is the term we use to describe any group of chemicals of interest to you. SciveraLENS is a flexible tool that is meant to work the way you do. You can create a Collection for a formulation, track your chemical inventory, create a , a list of chemicals within the same functional class (e.g. solvents) for easy comparison, or enter single CAS RNs or a list of chemicals that are related only because they are of interest to you, your team, or even your customers.Think of a Collection as a file folder or a simple way to organize your CAS RNs based on how you want to review the assessment results. 

To add a new Collection, go to the My Collections tab and click on the little green plus (+) button on your Collections page. This will take you to the Collection Builder Wizard, which offers five different workflows you can choose from to assist you in building your Collection.

To create a Collection with CAS RNs, you can choose from one of the first four workflows:

  • Quick Collection
  • BOS Builder
  • Upload BOS
  • Upload SDS

You can also create a Collection by using the Collection Assembler to link existing Collections (for example formulations you have already created a Collection for) and/or to request data from others to complete your assessment (for example a mixture that you purchase from a sub-supplier). You can also send requests in any of the first four Collection Builder methods listed above if needed.

As you go through the process of adding your Collections, the SciveraLENS system will provide you with helpful tips along the way and you can always contact our team for assistance (support@scivera.com).

 

Reviewing your Collection and Assessment Results:

Once we’ve processed your Collection, you’ll notice it will be listed on your Collections Index page. With our SciveraLENS Assessment Plans each Collection will have two symbols next to it. The first symbol (a colored triangle) indicates if any chemicals from your selected lists are present in the Collection. The second symbol (a colored circle) is a summary indication of the currently known human and environmental health attributes of the chemicals in the Collection across 23 toxicological endpoints. This summary hazard score is called the “Hazard Category” score or “HC” and is also available in the detailed assessment results table for each Collection. The summary columns available on your Collections Index page can help you quickly identify which Collections have certain characteristics so you can prioritize your work.

You can also tag and filter your Collections from this page for easier sorting and viewing. To tag your Collections, click on the three dot menu to the right of each Collection. To filter your Collections, click on the filter icon at the top right of your Collection Index page. 

When you click on the name of your Collection or on the View option from your Collection menu, you’ll be able to view the assessment results for your Collection. For each Collection, you will be able to view both a Summary tab and a Details tab. 

The Summary tab or dashboard provides a summarized view of the assessment results for your Collection. You’ll notice that rather than seeing a row for each CAS RN in the Collection, you’ll see all the CAS RNs have been rolled up into summary groupings, CAS RNs and what we call Child Collections. For example, if you build a Collection for a formulation with 3 CAS RNs and include a request for a mixture that you source from a supplier, you’ll see a row in the Summary tab for your CAS RNs and the name of the request you have sent. You’ll also see a summary of the assessment results for each grouping. In the summary dashboard, we want to help you flag any problematic chemicals so you’ll see if there are any restricted substances in the formulation/Collection based on the data you have entered as well as the worst or the highest Hazard Category results for each Child Collection. The donut chart on the right will show you based on % for each Child Collection, the overall HC assessment result. Under this summary table, you’ll also see a list of all of the lists that you have selected for screening. 

This Summary view can be a good one to share with your peers or customers to show what lists you have screened your chemicals against as well as if there are any problematic chemicals in your Collection without providing the detailed CAS RN view provided in the Details tab. 

The Collection Detail view presents all chemicals in the Collection in a table and provides you with an easy way to review Scivera’s list screening and chemical hazard assessment results for each chemical. The List column will show which of your chemical(s) are present on your List(s) of interest (these are selected when you create your Collection). You’ll also see Scivera’s chemical hazard assessment results. This matrix provides information across 23 human and environmental health endpoints for each chemical and what Scivera’s toxicologists have concluded about each. There are helpful tips available when you hover your pointer over each light. These tips will reveal a statement about each endpoint for each chemical. Clicking on each light will present the underlying references supporting our team’s assessment decision.

We’ve included a legend in the User Guide so you can remember what each light color indicates.

As you add more Collections, you’ll be able to manage and filter them on the Collections index page.

Managing your Lists:

Clicking on the Lists sidebar item will present to you with the lists and sublists that our team manages for your use in screening. Any or all are available to track when creating a Collection. You can mark your “favorite” lists or lists you refer to regularly. Lists that are marked as favorites will appear at the top of your Assign Lists screen when creating Collections for easy access and reference. To sort through this list more easily, check out the filter button at the top right of the Lists screen where you can search by list name and more.

Scivera manages and maintains over 400 lists and sublists and makes these available to SciveraLENS subscribers for instant screening. 

Scivera’s Toxicologists review hundreds of globally-recognized lists that are created by regulatory agencies, organizations, NGOs, etc. We add the lists that matter most to our customers into SciveraLENS so that you can quickly see if any of your chemicals appear on a list of interest. In addition to monitoring these lists and making sure that you always have the most complete and up-to-date list when screening your chemicals, our Toxicologists also expand any lists that include chemical groups or families. This means that we identify all CAS numbers associated with a chemical group or family so that you get the most complete and accurate screening results. If anything changes on a list that you’re tracking, you’ll receive real-time alerts letting you know of the change.

You’ll notice that our lists have identifiers in their titles so you can quickly see what category each list is in: 

  • Authoritative: Authoritative lists come from recognized experts that identify known hazards and are considered reliable and high confidence sources.
  • Examples include: IARC – Cancer Monographs Carcinogen Groups, NTP-OHAT Lists
  • Group: Group lists identify chemical groups, often these have known hazard characteristics but not all group lists indicate a particular hazard level.
    • Examples include: Aluminum, Azo Dyes, Mercury, Toluene Diisocyanates
  • Hazard: Hazard lists identify known hazards but are considered less authoritative and comprehensive sources. These hazards are assigned with lower confidence.
    • Examples include: AOEC – Asthmagens, Lancet – Grandjean & Landrigan Neurotoxic Chemical, TEDX
  • Inventory: Inventory lists do not indicate specific hazards, only that a CAS RN is present on a list of known chemicals generally by a regulatory body and/or country.
    • Examples include: Canada DSL
  • Organization: Organization lists include non-governmental organizations and other sources, these are often sector-specific.
    • Examples include: AAFA, Afirm, BIFMA, ChemSec, Cradle to Cradle, Safer Chemicals Healthy Families, ZDHC MRSL
  • Preferred: Preferred lists indicate low hazard, generally for a particular endpoint, but can also be for a chemical overall.
    • Examples include: EPA Safer Chemical Ingredient List
  • Regulatory: Regulatory lists are those published by regulatory authorities, these include country lists and specific agencies within countries.
    • Examples include: California Proposition 65, ECHA, EU REACH, Oregon Health Authority, US EPA, US FDA, Washington State CHCC

 

If you don’t see a list that you’re interested in, please let us know and we can work with you to add what you need. 

Alerts and Notifications:

The Alerts and Notifications section is where SciveraLENS will keep you apprised of any updates to your chemicals of interest related to changes in lists or underlying human/environmental health characteristics. If a change occurs to a list that affects one of your Collections, SciveraLENS will generate an alert on the Alerts page. This way, you’ll be able to quickly see any impacts to your Collections and chemicals of interest and be able to respond immediately since the system has done the work for you!

You can sort your Alerts by using the filter option in the top right of your screen. If this page is blank, you don’t have any alerts yet.

Managing Your Account:

In the top right of your screen, you’ll see your user name and icon. From here, you’ll be able to edit your profile, manage your account settings and billing profile, and logout.

Getting Started

Whether you signed up for our free trial of SciveraLENS or are just getting started with your new SciveraLENS account, here are some basic ways to get started.

Navigating your Collection index page

Your Collection Index page shows you all of the Collections that have been added to your account. You can access your assessment results for your Collections directly from this page as well as manage your Collections.

Sample Collections

When you log in to SciveraLENS for the first time, you’ll notice that you have two free sample Collections set up for you in your Collections window.

  • Sample Collection – PG vs. EG compare
  • Sample Collection 2 – Solvent compare

These Collections provide an example of different ways you can set up your own Collections when you’re ready to use SciveraLENS. Click on each of the links on the summary line to view the different reports available. Click on the:

  • Triangle for a report on List Hits by CAS RN
  • Circle, Collection name or CAS RNs for an Insight report showing you individual assessments for 23 human and environmental health endpoints and a report on List Hits by CAS RN
  • List Hits to view CAS RNs by List
  • 3 dots to the far right of the summary line to:
    • View your Collection report
    • Manage your Collection
    • Download a CSV or Bill of Substances for the CAS RNs in your Collection
    • Share your assessment results with others with redaction (redact the CAS RNs and chemical names upon sharing) or in full disclosure mode
    • Archive a Collection. You can view your archived Collections by using the filter on your Collections page
    • Tag your Collection. You can then filter on these tags for easy sorting and searching

 

Getting the Most your of your Free Trial: Adding new Collections

As part of the SciveraLENS free trial, we’ve included 6 sample chemicals that have been pre-loaded to help give you a feel for the functionality of the system. Below are some example Collections using the 6 pre-loaded chemicals that you can add to the system in order to test out each of the four Collection creation methods. You also have the ability to add up to 5 additional unique CAS RNs to test out SciveraLENS.

SciveraLENS organizes your chemicals of interest into Collections. A Collection of chemicals can be a single chemical, or a list of chemicals. Your list of chemicals can be a formulation for a product, or it could be a list of chemicals that you would like to compare for use in a specific application. Collections can be chemicals organized for any purpose. The way you organize your Collections is only limited by your imagination or chemicals management needs.

Create Collections in SciveraLENS using one of five different methods: (The CAS RNs included in these examples will not count against your CAS RN count in SciveraLENS.)

  1. Create a Quick Collection*
    1. Add a Collection name
    2. Type or copy and paste your chemicals into the CAS RNs field
      1. Here are some CAS RNs you can enter into the CAS RNs field (make sure you’re just copying or entering the CAS RN from the list below):
        1. 7732-18-5
        2. 5131-66-8
        3. 111-77-3
    3. Import existing Collections or request data from others if needed
    4. Add supporting documents if needed
    5. Assign the Regulated, Screening, or Preferred Chemical Lists against which you’d like to review/track your Collection
  2. Use the 5-step “BOS Builder” web wizard*
    1. Name your Collection
    2. Add chemicals of interest by name or CAS RN (Chemical Abstract Service Registry Number) and concentration
      1. Here is a list of 3 chemicals to use in the BOS Builder web wizard to create a Collection using this method: (These CAS RNs will not count against your CAS RN limit in SciveraLENS)
        1. Water [CAS RN: 7732-18-5] 75% (use decimal value of 0.75 for concentration)
        2. 1-butoxypropan-2-ol [CAS RN: 5131-66-8] 20% (aka 0.2)
        3. 2-(2-methoxyethoxy)ethanol [CAS RN: 111-77-3] 5% (aka 0.05)
    3. Import existing Collections or request data from others if needed
    4. Add supporting documents if needed
    5. Assign the Regulated, Screening, or Preferred Chemical Lists against which you’d like to review/track your Collection. By the way, BOS is an acronym for “bill of substances.” A BOS is a data document, similar to the long used term, BOM, (bill of materials) but with the additional information of specific chemicals that make up each material.
  3. Upload a Bill of Substances (BOS)*. You can create a BOS file in the form of a spreadsheet and upload it to your SciveraLENS account for screening a tracking. There is a specific format for the data (i.e., basic fields, etc) needed for a successful upload. You can find a template of this format here. This approach can be very useful for large Collections or for pulling data from an existing data resource. Feel free to check with our Support Team if you’d like to discuss bulk data import from an existing system to your SciveraLENS account.
  4. Upload a Safety Data Sheet (SDS)*. Start your Collection by uploading a text-based PDF of your Safety Data Sheet. SciveraLENS will pull out the relevant information from the SDS to create your Collection. As part of this process, you will also have the option to import existing Collections or request data from others and add supporting documents if needed.
  5. Use the Collection Assembler* to combine existing Collections into a new Collection. After filling in the basic information including Collection Name, you can import existing Collections from your own SciveraLENS account or request data from another SciveraLENS user. Then add supporting documents if needed and assign lists.

*To learn more about the different Collection Builder options in SciveraLENS, check out the specific User Guide article for each.

Ready to add a Collection?

To create a Collection using one of the above methods, click on “My Collections” in the navigation menu on the left side of your SciveraLENS app window (see red circle in image below).

Then click on the green circle with a “+” symbol in the upper right of the window.

It will take you to the Collection Builder Wizard, which offers five different methods you can choose from to assist you in building your Collection.

Give it a try. Send us a note if you have any trouble creating a Collection or check out the specific User Guide articles for each of the five Collection creation options.

 

Review screening results for each Collection (or how to get answers to your chemicals management questions, instantly)

When in the Collections page, you will see your current list of Collections. Each Collection will include two symbols to the left of the Collection name. The triangle symbol shows the result of the List Screen completed for the chemicals in each Collection. The circle symbol shows the summarized hazard assessment score for the chemicals in each Collection. 

Triangles:

The triangular symbol indicates whether or not there were any list “hits” for the chemicals in your Collection.

(Note – If you don’t put a concentration in for your chemicals (for example, when using Quick Collection), we assume 100% concentration for a chemical if not otherwise indicated.)

Circles:

The circular symbol (aka “traffic light”) is the instant result of the Human and Environmental Health Screen for the chemicals in the Collection.

   Green is good. Green lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of low hazard. The Green/Gray light means Low Hazard based on limited evidence only (e.g., modeling, QSAR, etc.).

Yellow is acceptable. Yellow lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of moderate hazard. The Yellow/Gray light means Moderate Hazard based on limited evidence only (e.g., modeling, QSAR, etc.).

  Red indicates concern. Red lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of high hazard. The Red/Gray light means High Hazard based on limited evidence only (e.g., modeling, QSAR, etc.).

 Black indicates high concern. Black lights signal an overall assessment for a chemical or a specific human or environmental health endpoint shows evidence of high hazard. The Black/Gray light means Very High Hazard based on limited evidence only (e.g., modeling, QSAR, etc.).

Light blue indicates potential, but with caution. Light blue signals the endpoint does not show concern for the designated endpoint based on list evidence only but we have not yet completed a comprehensive hazard assessment on that particular chemical or endpoint. To complete this assessment and verify the Hazard Category score for a particular chemical, contact Scivera, and we can get the assessment prioritized for completion. 

The light blue and gray light indicates an endpoint or chemical overall that does not show list evidence of concern, but after additional work by our toxicology team, we are not currently able to conclude an assessment. Data are currently not sufficient for an assessment.

The “MH” or Maximum Hazard result is based on the highest hazard assessment across all chemicals in the Collection and across all Human Endpoints and a combination of Environmental Health Endpoints for each chemical.

The “HC” or Hazard Category Score is based on an algorithm very similar to EPA Safer Choice, etc. that uses Core Endpoints (CMRD/PBT) and Supplemental Endpoints (all the rest) and suggests a Replace (Red Light), Concern (Yellow Light), Acceptable (Yellow/Green), Preferred (Green), or Incomplete (Gray)

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